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CH3O1-Advanced Organic Chemistry - Synthesis of Complex Targets

Module Provider: Chemistry, School of Chem, Food and Nutr Sci, and Pharm
Number of credits: 10 [5ECTS credits]
Level: 6
Terms in which taught: Autumn
Module Convenor: Professor LM Harwood
Pre-requisites: CH2O1
Co-requisites:
Modules excluded:
Module version for: 2009/0

Email: l.m.harwood@reading.ac.uk

Aims:
To extend the synthetic methods introduced in previous years to the preparation, characterisation and manipulation of macromolecules and materials of biological and synthetic origin.

Assessable learning outcomes:
Students who have successfully completed this module will be able to:

  • Describe the various classes of chiral molecules that are available from natural sources.
  • Outline the use of these chiral precursors in the synthesis of more complex natural products.
  • Be able to choose appropriate methods for the synthesis of specific polymers.
  • Outline the relationship between structure and physical characteristics of macromolecular materials.

    Additional outcomes:
    Lectures will provide an overview of the synthesis and utility of natural and non-natural monomer units and their assembly into complex polymers. Students will gain experience of the chemistry used in the construction of such complex materials via small group tutorials.

    Outline content:
    G Brown (10 lectures) Introduction to the Chemistry of the Chiral Pool
    A survey of basic amino acid synthesis; N- and C-terminal protection and activation; peptide coupling in solution and in the solid phase. Structures, typical reactions, protection and use of carbohydrates in synthesis.
    F J Davis (10 lectures) Polymer Chemistry
    Radical, cationic and anionic polymerisation processes and the structural classes of the polymers that may be formed. Molecular weight determination, polymer characterisation.

    Brief description of teaching and learning methods:
    Two one hour lectures per week with approximately one tutorial on related material every two weeks.

    Contact hours:

      Autumn Spring Summer
    Lectures 20
    Tutorials/seminars    
    Practicals      
    Other contact (eg study visits)      
    Total hours 23     
    Number of essays or assignments      
    Other (eg major seminar paper)      

    Assessment:
    Coursework
    Students will attend 3 tutorials on the material covered in this module. Attendance is compulsory. A tutorial comprises both written work and oral contribution. A maximum of 20 marks is available for the written work and 5 marks for the oral contribution for each tutorial set.

    For students on chemistry-based degree courses any unexplained absence from more than two tutorials in chemistry in any term will automatically incur a formal warning from the School Director of Teaching and Learning.

    Tutorial work and oral contribution at tutorials 20%

    Examinations
    A one and a half-hour written paper taken during the Part 3 examinations period. 80%

    Requirements for a pass
    A mark of 40% overall.

    Reassessment arrangements
    Re-examination will take place in the September following final examination, for the examinable component only, when a student has failed the programme overall.

    Last updated: 23 November 2009

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